ACBI1 is a potent PROTAC degrader that cooperatively degrades SMARCA2, SMARCA4, and PBRM1, with DC50 values of 6, 11, and 32 nM respectively. It exhibits anti-proliferative activity and induces apoptosis. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase von Hippel-Lindau.
- Potent and cooperative degrader of SMARCA2, SMARCA4, and PBRM1
- Exhibits anti-proliferative activity in vitro
- Induces apoptosis
- Composed of a bromodomain ligand, a linker, and E3 ubiquitin ligase
- Soluble in DMSO (≥ 100 mg/mL)
- Suitable for in vivo applications with specific solvent systems